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Publications

Publications

Compensation between CSF1R+ macrophages and Foxp3+ Treg cells drives resistance to tumor immunotherapy

8 June 2018/in Publications /by circlek

Compensation between CSF1R+ macrophages and Foxp3+ Treg cells drives resistance to tumor immunotherapy
David Gyori, Ee Lyn Lim, Francis M. Grant, Dominik Spensberger, Rahul Roychoudhuri, Stephen J. Shuttleworth, Klaus Okkenhaug, Len R. Stephens, Phillip T. Hawkins
JCI Insight 2018, 3(11), e120631

/wp-content/uploads/2019/04/logo_karustx.png 0 0 circlek /wp-content/uploads/2019/04/logo_karustx.png circlek2018-06-08 12:15:272019-04-16 12:15:49Compensation between CSF1R+ macrophages and Foxp3+ Treg cells drives resistance to tumor immunotherapy

Inhibition of histone deacetylase 6 reveals a potent immunosuppressant effect in models of transplantation.

1 June 2018/in Publications /by circlek

Inhibition of histone deacetylase 6 reveals a potent immunosuppressant effect in models of transplantation.
Ellis J, Neil D, Inston N, Jenkinson E, Drayson M, Hampson P, Shuttleworth S, Ready A, Cobbold M.
Transplantation 2016, 100(8), 1667

/wp-content/uploads/2019/04/logo_karustx.png 0 0 circlek /wp-content/uploads/2019/04/logo_karustx.png circlek2018-06-01 12:16:242019-04-16 12:16:44Inhibition of histone deacetylase 6 reveals a potent immunosuppressant effect in models of transplantation.

Functional characterization of a novel somatic mutation of PIK3CB

20 November 2017/in Publications /by circlek

Functional characterization of a novel somatic mutation of PIK3CB
Whale AD, Colman L, Lensun L, Rogers HL, Shuttleworth SJ
Signal Transduction and Targeted Therapy 2017, volume 2, 17063

/wp-content/uploads/2019/04/logo_karustx.png 0 0 circlek /wp-content/uploads/2019/04/logo_karustx.png circlek2017-11-20 12:15:572019-04-16 12:16:17Functional characterization of a novel somatic mutation of PIK3CB

Targeting PI3K pathway in ibrutinib resistant diffuse large B-cell lymphoma

1 April 2017/in Abstracts, Publications /by circlek

Targeting PI3K pathway in ibrutinib resistant diffuse large B-cell lymphoma.
Jain N., Seghal L., Shuttleworth S.J., Samaniego F.
Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 2366.

/wp-content/uploads/2019/04/logo_karustx.png 0 0 circlek /wp-content/uploads/2019/04/logo_karustx.png circlek2017-04-01 12:02:192019-07-11 16:06:56Targeting PI3K pathway in ibrutinib resistant diffuse large B-cell lymphoma

Pre-Clinical Evaluation of the PI3K-p110ß/δ Inhibitor KA2237 in Mantle Cell Lymphoma

3 December 2016/in Abstracts, Publications /by circlek

Pre-Clinical Evaluation of the PI3K-p110ß/δ Inhibitor KA2237 in Mantle Cell Lymphoma.
Huang S., Nastoupil L.J., Guo H., Bell T., Ahmed M., Li C.J., Wang J., Liu Y.,  Zhang V., Kim C.R., Boyle J.N., Lorence E.A., Lam L.T., Chen Z., Zhang H., Shuttleworth S.J., Nomie K., Wang M., Zhang L.
Abstract 1837. 58th ASH Annual Meeting and Exposition, San Diego, CA, December 3-6 2016.

/wp-content/uploads/2019/04/logo_karustx.png 0 0 circlek /wp-content/uploads/2019/04/logo_karustx.png circlek2016-12-03 12:03:092019-07-11 16:07:03Pre-Clinical Evaluation of the PI3K-p110ß/δ Inhibitor KA2237 in Mantle Cell Lymphoma
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