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Compensation between CSF1R+ macrophages and Foxp3+ Treg cells drives resistance to tumor immunotherapy
/in Publications /by circlekCompensation between CSF1R+ macrophages and Foxp3+ Treg cells drives resistance to tumor immunotherapy
David Gyori, Ee Lyn Lim, Francis M. Grant, Dominik Spensberger, Rahul Roychoudhuri, Stephen J. Shuttleworth, Klaus Okkenhaug, Len R. Stephens, Phillip T. Hawkins
JCI Insight 2018, 3(11), e120631
Inhibition of histone deacetylase 6 reveals a potent immunosuppressant effect in models of transplantation.
/in Publications /by circlekInhibition of histone deacetylase 6 reveals a potent immunosuppressant effect in models of transplantation.
Ellis J, Neil D, Inston N, Jenkinson E, Drayson M, Hampson P, Shuttleworth S, Ready A, Cobbold M.
Transplantation 2016, 100(8), 1667
Functional characterization of a novel somatic mutation of PIK3CB
/in Publications /by circlekFunctional characterization of a novel somatic mutation of PIK3CB
Whale AD, Colman L, Lensun L, Rogers HL, Shuttleworth SJ
Signal Transduction and Targeted Therapy 2017, volume 2, 17063
Targeting PI3K pathway in ibrutinib resistant diffuse large B-cell lymphoma
/in Abstracts, Publications /by circlekTargeting PI3K pathway in ibrutinib resistant diffuse large B-cell lymphoma.
Jain N., Seghal L., Shuttleworth S.J., Samaniego F.
Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 2366.
Pre-Clinical Evaluation of the PI3K-p110ß/δ Inhibitor KA2237 in Mantle Cell Lymphoma
/in Abstracts, Publications /by circlekPre-Clinical Evaluation of the PI3K-p110ß/δ Inhibitor KA2237 in Mantle Cell Lymphoma.
Huang S., Nastoupil L.J., Guo H., Bell T., Ahmed M., Li C.J., Wang J., Liu Y., Zhang V., Kim C.R., Boyle J.N., Lorence E.A., Lam L.T., Chen Z., Zhang H., Shuttleworth S.J., Nomie K., Wang M., Zhang L.
Abstract 1837. 58th ASH Annual Meeting and Exposition, San Diego, CA, December 3-6 2016.